UCSF HemeOnc Resident Lectures

Coagulation

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Anemia

(from Mary Wang - Iron Deficiency and Other Types of Anemia in Infants and Children)

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Iron deficiency anemia & thalassemias
Parameter Iron deficiency
anemia α-Thalassemia
minor β-Thalassemia
minor
MCV ↓ ↓ ↓
RDW ↑ Normal Normal
RBCs ↓ Normal/↑ Normal/↑
Peripheral
smear Microcytosis,
hypochromia Target cells Target cells
Serum iron
studies ↓ Iron & ferritin
↑ TIBC Normal/↑ iron & ferritin
(RBC turnover) Normal/↑ iron & ferritin
(RBC turnover)
Response to iron
supplementation ↑ Hemoglobin No improvement No improvement
Hemoglobin
electrophoresis Normal Normal ↑ Hemoglobin A2
MCV = mean corpuscular volume; RBCs = red blood cells; RDW = red blood cell distribution width; TIBC = total iron-binding capacity.